Effects of Isoliensinine on Experimental Arrhythmia and Myocardium Action Potential of Guinea Pig
- VernacularTitle:异莲心碱抗实验性心律失常作用及对豚鼠心肌动作电位的影响
- Author:
Fan ZHANG
;
Jialing WANG
;
Jiaqin QIAN
- Publication Type:Journal Article
- Keywords:
isoliensinine arrhythmia model action potential mechanism of action
- From:
Chinese Traditional and Herbal Drugs
2000;31(10):753-755
- CountryChina
- Language:Chinese
-
Abstract:
Antiarrhythmic effect of isoliensinine (IL) was studied on experimental arrhythmic mo-dels induced by coronary artery ligation and 4 different arrhythmogenic drugs in comparison with quinidine(Qu). Results of the study showed that the antiarrhythmic potency of IL was stronger than that of Qu atthe same dosage. The effects of IL on fast and slow response action potentials of myocardium were ob-served in guinea pig papillary muscles by standard microelectrode technique, which showed that IL couldreduce APA and Vmax and shorten the APD50. The results suggested that the antiarrhythmic mechanismof IL is related to its non-specific inhibition of the currents of Na+ and Ca2+.
