The Efficacy of Bupivacaine Combined with Midazolam Tramadol or Fentanyl on Patient-controlled Epidural Analgesia
- VernacularTitle:布比卡因分别复合芬太尼、咪唑安定或曲马多用于术后硬膜外自控镇痛的比较
- Author:
Hong LI
;
Guolin WANG
- Publication Type:Journal Article
- Keywords:
Epidural Patient-controlled analgesia Bupivacaine Fentanyl Midazolam Tramadol
- From:
The Journal of Clinical Anesthesiology
2000;16(9):444-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the efficacy of bupivacaine alone or combined with fentanyl, midazolam or tramadolduring PCEA. Methods:Sixty patients scheduled for abdominal hysterectomy under combined epidural and spinal anesthesiawere randomly divided into four groups. Group A received 0. 125 % bupivcaine, group B 0. 125 % bupivacaine + fentanyl(2.5tg/ml), group C 0.125 % bupivacaine + midazolam(0.5mg/ml), group D 0. 125 % bupivacaine + tramdol(3mg/ml).PCEA parameters were a loading dose of 6mi, a bolus dose of 3mi, a lockout interval of 30 min and continuous infusion of2ml/h. The total drug dosage was recorded for up to 24h after operation. The number of PCEA demand, visual analogue painscales(VAS), sedation scales, the incidence of nausea and vomiting, respiratory rate (RR) and mean arterial pressure (MAP)were measured at 4h, 8h, 12h and 24h postoperatively. Results: The total drug dosage, number of button pressed and VAS ingroup A were significantly higher than those in the other groups( P < 0.01 ), which was the least in group D. The sedationscales were the highest in group C. There was a higher incidence of nausea and vomiting in group B. Conclusions: Bupivacainecombined with fentanyl, midazolam or tramadol used for PCEA produces higherquality of pain relief than bupuvacaine alone.
