Studies on the Chemical Constituents of Japanese Buckeye Seed (Aesculus turbinata)Part Ⅱ * Isolation and Identification of Escin IVc and Isoescins Ia, Ib
- VernacularTitle:日本七叶树化学成分的研究△Ⅱ．七叶树皂苷IVc和异七叶树皂苷Ia、Ib的分离和鉴定
- Author:
Xiuwei YANG
;
Jing ZHAO
;
Masao HATTORI
- Publication Type:Journal Article
- Keywords:
Aesculus turbinata B1. triterpenes escin IVc isoescin Ia isoescin Ib
- From:
Chinese Traditional and Herbal Drugs
2000;31(9):648-651
- CountryChina
- Language:Chinese
-
Abstract:
Three triterpenoid saponins were isolated from 90％ ethanolic extract of the seeds of Aes-culus turbinata Bl.. Their structures were identified on the basis of spectral data as escin IVc:22α-O-tigloyl-28-O-acetylprotoaescigenin 33-O-[β-D-glucopyranosyl (1→2)][β-D-glucopyranosyl (1→4)]-β-D-glucopyranosiduronic acid (Ⅰ), isoescin Ia: 21β-O-tigloyl-28-O-acetylprotoaescigenin-3β-O-[β-D-glucopy-ranosyl (1→2)][β-D-glucopyranosyl (1→4)]-β-D-glucopyranosiduronic acid (Ⅳ), and isoescin Ib:21β-O-angeloyl-28-O-acetylprotoaescigenin-3β-O-[β-D-glucopyranosyl (1→2)][β-D-glucopyr anosyl (1→4)]-β-D-glucopyranosiduronic acid (Ⅴ). Escin IVc and isoescins Ia, Ib were obtained for the first time from thisplant. Escins Ia, Ib, IVc and isoescins Ia, Ib had inhibitory effect against recombinant HIV-1 protease atconcentration of 100 μmol/L in vitro.
