Studies on Anti-Inflammatory Mechanisms of Saponin of Panax pseudo-ginseng var. notoginseng (Sanchi)
- VernacularTitle:三七总皂苷抗炎作用机制的实验研究
- Author:
Shuhui LI
;
Xiaohui LI
;
Yan CHU
- Publication Type:Journal Article
- Keywords:
saponin of Panax pseudo-ginseng var. notoginseng (Burk.) Hoo et Tseng air pouchsynovitis malondialdehyde O2- cAMP
- From:
Chinese Traditional and Herbal Drugs
2000;31(9):676-678
- CountryChina
- Language:Chinese
-
Abstract:
Effects of saponin of Panax pseudo-ginseng var. notoginseng (Burk.) Hoo et Tseng(PnS) on neutrophil (Neu) count, protein and malondialdehyde (MDA) contents in the exudate of rat a-cute air pouch synovitis model induced by sc injection of 25 mg/kg carrageenan were investigated by Lowryand test tube dilution methods and thiobarbituric acid spectrophotometry. Its effects on the intracellularcAMP content in and release of O2 from Neu were further assessed by radioimmunoassay and cytochromeC reduction methods respectively. The results showed that PnS 60,120,240 mg/kg ip reduced the migra-tion of Neu and exudation of protein, lowered the content of MDA and inhibited the release of O2- fromNeu; but elevated the cAMP content of Neu in a dose-dependent manner. These results revealed that Pnshas an obvious anti-inflammatory effect and its primary action was related to the increase of cAMP contentin Neu, followed by inhibition of the free radical production.
