Telmisartan-induced sprue-like enteropathy: a case report and a review of patients using non-olmesartan angiotensin receptor blockers.
- Author:
Harshal Surendra MANDAVDHARE
1
;
Vishal SHARMA
;
Kaushal K PRASAD
;
Amit KUMAR
;
Manish RATHI
;
Surinder S RANA
Author Information
- Publication Type:Case Report
- Keywords: Celiac disease; Diarrhea; Malabsorption; Angiotensin receptor blockers
- MeSH: Angiotensin Receptor Antagonists*; Angiotensins*; Atrophy; Celiac Disease; Diarrhea; Duodenum; Endoscopy; Female; Humans; Hypertension; Hypothyroidism; Middle Aged; Olmesartan Medoxomil; Pectinidae; Renal Insufficiency, Chronic; Upper Gastrointestinal Tract; Valsartan; Weight Loss
- From:Intestinal Research 2017;15(3):419-421
- CountryRepublic of Korea
- Language:English
- Abstract: Recent studies have identified sprue-like illness associated with the use of the antihypertensive agent olmesartan medoxomil. However, whether this condition is specific to the use of olmesartan or is associated with the use of drugs belonging to the class of “sartans” remains to be clarified. A 45-year-old woman with chronic kidney disease along with hypothyroidism and hypertension presented with chronic diarrhea and significant weight loss. Endoscopy of the upper gastrointestinal tract showed scalloping and grooving of the duodenum, and histopathological examination showed subtotal villous atrophy. She was on telmisartan for hypertension, which was discontinued. Subsequently, diarrhea ameliorated dramatically, and she regained weight. To our knowledge, this is the first study to report telmisartan-associated sprue-like enteropathy. Further, we have reviewed the cases of patients with sprue-like enteropathy caused by valsartan, irbesartan, and eprosartan.
