Lipopolysaccharide stimulates TNFα and endothelin- 1 secretion from cultured rat kupffer cells
- VernacularTitle:不同剂量内毒素刺激枯否细胞分泌肿瘤坏死因子-α及内皮素-1的体外观察
- Author:
Lixin LIU
;
Dewu HAN
- Publication Type:Journal Article
- Keywords:
Lipopolysaccharides;
Kupffer cells;
Tumor necrosis factor;
Endothelins
- From:
Chinese Journal of Pathophysiology
2000;16(12):1298-1300
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate LPS(lipopolysaccharide)stimulated cytokine secretion from normal rat kupffer cells in vitro. METHODS: Kupffer cells were isolated from wistar rats liver and cultured. Tumor necrosis factor - α (TNF- α) and endothelin- 1 (ET- 1 ) secreted by LPS stimulated kupffer cells were detected. RESULTS: LPS had an stimulative effect on kupffer cell activity. LPS in definite concentrations promoted kupffer cell secretion. CONCLUSION: LPS promotes kupffer cell secretion, which may be associated with liver injury induced by LPS.
