Role of P97 in non- transferrin bound iron uptake by rabbit reticulocytes
- VernacularTitle:黑素转铁蛋白在家兔网织红细胞非转铁蛋白结合铁摄取中的作用
- Author:
Wenfang CHEN
;
Zhongming QIAN
- Publication Type:Journal Article
- Keywords:
Transferrin;
Iron;
Reticulocytes
- From:
Chinese Journal of Pathophysiology
2000;16(12):1317-1319
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the possible role of P97 in non - transferrin bound iron uptake by rabbit reticulocytes. METHODS: The iron uptake were measured by the method of radioisotope (5gFe). RESULTS: (1) Only PI - PLC treatment had no apparent effect on iron uptake by reticulocytes (P > 0.05); (2) Reticulocytes, pretreated by pronase and then by PI - PLC, give a significant decrease in iron uptake in cytosol and in hemne ( P < 0.01). CONCLUSION: The results support the possibility that P97 might be able to be expressed on the membrane of reticulocytes and plays a role in non - transferrin bound iron uptake by this type of cells in the rabbit.
