Influence of puerarin injection(葛根素注射液) on endothelial functions in patients with variant angina pectoris

VernacularTitle:葛根素注射液对变异型心绞痛患者内皮功能的影响
Author: Zhize JIN ; Jinyun MA
Publication Type:Journal Article
From: Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2001;8(1):31-32
CountryChina
Language:Chinese
Abstract: Objective:To observe the curative effects of puerarin injection(葛根素注射液) on variant angina pectoris(VAP) and its influences on endothelial functions.Methods:Fortyeight cases with VAP were randomly divided into treated and control group.The treated group was treated with puerarin injection 300500 mg infused intravenously once a day，meanwhile the control group treated with conventional therapy.The therapeutic course was 1014 days for both groups.Before and after using drugs the changes in endothelin(ET) and nitric oxide (NO) were observed in two groups.Results:In both groups after therapy the clinically symptomatic convalescences and changes in electrocardiography (ECG) compared with before therapy had significant differences,but in comparison between two groups the differences had not statistical significant.Otherwise regarding to the ET and NO the differences were significant between treated group and control group.Conclusions:Puerarin injection not only possesses obviously curative effects on symptomatic convalescence and ECG changes but also is able to improve the endothelial functions.