Effects of Jinma Tongluo Capsule on Micronucleu s of Mice Marrow Cells
- VernacularTitle:金马通络胶囊对小白鼠骨髓细胞微核的影响
- Author:
Guangli RAO
;
Guilan LI
;
Yungqing GUO
;
Jiangping CHEN
- Publication Type:Journal Article
- Keywords:
@JinmaTongluo capsule/toxicity;
Flos Daturae/toxicity;
@rates of micronucleus
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2001;12(1):36-37
- CountryChina
- Language:Chinese
-
Abstract:
Effects of Jinma Tongluo capsule (JT C) on the incidence of micronucleu s of marrow cells in mice with Kunming species were reported. JTC intragastric d osages of 100 mg/kg, 400 mg/kg, 1600 mg/kg (equivalent to 3, 12 and 48 times of the clinical dosage respectively) were given to the mice.Twenty-four hours later th e mice were e xecuted and the marrow cells were examined. The incidence of micronucleus was 2 .00‰, 1.83‰, 2.17‰ respectively. In the group of dosage of 1600 mg/kg, the inci dence was maintained in the normal limits within 12～72h. And the differences we r e not significant as compared with the negative group and the solvent control gr oup. It's indicated that ig total alkalin of Flos Daturae under 0.86 mg/kg has no effect on micronucleus of mice marrow cells.
