Left Ventricular Hypertrophy to Heart Failure in Gradually Pressure Afterload Heart of Wistar Rat
- VernacularTitle:大鼠慢性压力后负荷心肌肥厚-心力衰竭模型的建立
- Author:
Feng XU
;
Jing DI
;
Shuling BAI
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(1):9-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Our purpose was to establish an ideal chronic pressure-afterload heart failure rat model which has the transition from cardiac hypertrophy to heart failure. Methods: Chronic pressure-afterload heart failure rat model was induced by gradually constricting the ascending aorta of young rats. Young rats were randomly divided into 2 groups: the constricted and sham-operated groups. Clinical manifestation, tail-cuff blood pressure, organ weight, and hemodynamic data were observed at various time after operation. Results: The overall survival rate was 87%. Tail-cuff pressure began to increase in 4 weeks after operation. Left ventricular hypertrophy appeared in 12 weeks and heart failure in 5 months. Conclusion:It's a practical and reproducible model of cardiac hypertrophy that progresses to chronic heart failure.
