The Influence of Immune RNA on Endotoxin-Induced Uveitis
- VernacularTitle:特异性免疫核糖核酸对内毒素诱导的实验性葡萄膜炎的抑制作用
- Author:
Ling QIN
;
Wei XIAO
;
Qing WAN
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(1):18-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Our aim was to investigate whether the immune RNA (iRNA) can inhibit the endotoxin-induced uveitis (EIU). Methods: The EIU was induced by injecting endotoxin of E.Coli into rats hypodermically. iRNA was abstracted from the livers and spleens of the rabbits which had been injected by E.Coli six times. The iRNA was introduced intraperitoneally into the rats both at half an hour and 3 hours after the injection of endotoxin. The effect of iRNA was evaluated by protein determination and cell count in aqueous houmer(AH). Results: The appearance of EIU in the iRNA treated rats was delayed, about 3 hours later than the rats received only endotoxin injection. The AH protein decreased by 58.34% and cellular infiltration decreased by 27.62% in iRNA treated group at the 24 hours. Conclusion: The iRNA may partly prevent the development of EIU and significantly reduce the severity of EIU.
