Effect of SP on Electroactivities of Thermo-Estradiol Related Sensitive Neurons in PO/AH of Rats
- VernacularTitle:P物质对大鼠PO/AH温度—性敏感神经元放电活动的影响
- Author:
Ying CHEN
;
Jiadi FENG
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The aim of this study was designed to certify the effects of substance P(SP) on thermo-gonohormonal neuron. Methods: We used the technique of extracellular microelectrode recording, and examined the effects of intravenously injections of SP on electroactiveties of thermo-gonohormonal neurons in PO/AH of rats. Results: Total of 9 warm-estradiol sensitive and 4 cold-estradiol sensitive neurons were recorded in PO/AH, where estradiol excited electroactivities of the warm-estradiol sensitive neurons but inhibited those of the cold-estradiol sensitive ones. While SP reversed the effects of estradiol bezonate on the above mentioned neurons. Conclusion: From our results and related data we may draw conclusions that the thermoregulatory effects of SP may be functioned via hermo-gonohormonal neuron.
