Studies on the actions of Xiefei Dingchuan injection(泻肺定喘注射液) on Ca2＋Mg2＋ATPase and Na＋K＋ATPase of red blood cell membrane in rats with pulmonary hypertension induced by monocrotaline
- VernacularTitle:泻肺定喘注射液对野百合碱诱发大鼠肺动脉高压的红细胞膜Ca2＋Mg2＋ATP酶和Na＋K＋ATP酶的研究
- Author:
Xudong XIONG
;
Xiaohong SHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2001;8(1):3-5
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the mechanism of Xiefei Dingchuan injection (XFDCI,泻肺定喘注射液) in treating pulmonary hypertension by means of measuring the activity of Ca2＋Mg2＋ ATPase and Na＋K＋ATPase of red blood cell(RBC) membrane.Methods:The pulmonary hypertension models induced by monocrotaline in 18 rats were established then treated with XFDCI.Using cardiac catheter and chromatometry respectively the pulmonary artery pressure (PAP) and the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane were measured.Results:The activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane in XFDCI group were obviously higher than those in pulmonary hypertension group.Conclusions:XFDCI is able to reduce the pulmonary hypertension and its mechanisms may be related to increasing the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane.
