Endothelial protein activated by acetylcholine
- VernacularTitle:血管内皮细胞乙酰胆碱激活蛋白
- Author:
Lili WANG
;
Hai WANG
;
Wenbin XIAO
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
EPA exists wildly in artery vascular endothelium and could be activated by endogenously activated substances and regulate the vascular tone. The endothelium-dependent vascular relaxation mediated by EPA has been used for almost 20 years as an indicator of endothelium dysfunction. In many cardio-vascular diseases, EPA function was down-regulated. The pharmacological profiles of EPA could be characterized by muscarinic properties, as well as non-muscarinic properties in selectivity for agonists and antagonists and in binding characteristics. The endogenous ligand, receptor type and molecular pharmacological characteristics of EPA are waiting to be investigated.
