Progress in the studies of endomorphins
- VernacularTitle:内吗啡肽研究进展
- Author:
Weihua REN
;
Xiaofeng HUO
;
Ning WU
;
Rui WANG
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Endomorphins(EMs),two tetrapeptides, were discovered in 1997 and believed to be endogenous ligands of μ-opioide receptor(MOR). They mediated various physiological processes by binding to MOR that couple with G-proteins. Based on our works and literatures, we reviewed the distribution in nerve system, receptor binding properties, analgesis, effects on ion channels, conformation and struction-activity relationship of EMs.
