Cytochrome P450 and genetic polymorphism
- VernacularTitle:细胞色素氧化酶P450及其遗传多态性
- Author:
Liangqing FU
;
Dezheng WU
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):21-25
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 enzyme are an important enzyme family in drug metabolism. Human cytochrome P450 enzymes have been studied entensively about their polymorphism in recent years. polymorphism of CYP2C19 and CYP2D6 have been detected at both phenotypic and genotypic level, and their molecular mechanism have been studied entensively, however, the molecular mechanism of other enzymes for exzample CYP2C9,CYP1A1,CYP2E1 et al) is being discussed, though these enzymes possiblely exist polymorphism. The article summarizes the substrates of P450, molucular mechanism of polymorphism, and paticular reference to the effects of this variation on drug metabolism and susceptibility to chemically-induced diseases.
