Structural and functional remodeling of thoracic aortae in sinoaortic-denervated rats
- VernacularTitle:去窦弓神经大鼠的胸主动脉重构
- Author:
Xia TAO
;
Chaoyu MIAO
;
Hong CHENG
;
Dingfeng SU
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the structural and functional remodeling of thoracic aortae in sinoaortic- denervated (SAD) rats. METHODS SD rats underwent either SAD or sham-operation at the age of 10 weeks. Sixteen weeks after operation, the contraction and relaxation of the thoracic aortae were measured in isolated preparations; The morphological changes of arteries were examined by using histopathological method and computer image analysis. RESULTS The NE-induced contraction was increased and Ach-induced relaxation of aortic rings was depressed in SAD rats; The structural remodeling of thoracic aortae was characterized by medial VSMC hypertrophy and matrix accumulations. CONCLUSION Vascular functional and structural remodeling can be found in sinoaortic-denervated rats.
