The effect of Houttuyninum on cellar immunoiogic function in splenectomy animals
- VernacularTitle:合成鱼腥草素对脾切除动物细胞免疫功能的影响
- Author:
Lan SHAO
;
Qinghai YU
;
Qing HUANG
;
Shusen LIU
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigated the effect and mechanism of Houttuynium (HOU) on splenectomy animals. METHODS The models of splenectomy mice and splenectomy rats were made and delayed type hypersensitivity (DTH) reaction, ANAE (+) cell percentage of peripheral blood lymphocytes, Con A-induced thymus and groin lymph node lymphocyte proliferation, the amount of lymphocytes of groin lymph node,and T cell subpopulation in peripheral blood were measured. RESULTS HOU ig (60 mg*kg-1, 120 mg*kg-1) can strikingly enhanced delayed type hypersensitivity (DTH) reaction, ANAE(+) cell percentage of peripheral blood lymphocytes. strengthened Con A-induced groin lymph node lymphocyte proliferation, raised the amount of lymphocytes of groin lymph node in splenectomy mice. But the effects of them on Con A-induced thymus lymphocyte proliferation were not apparent. HOU ig (40 mg*kg-1, 80 mg*kg-1) improved Th subset, reduced Ts subset, and then modulated the rate of Th/Ts in splenectomy rats. CONCLUSION HOU strengthened the cellar immune function of splenectomy animals by promoting the compensating capability of lymph node and regulating T cell subpopulation.
