Primary study of transmembrane transport of zinc and its mechanism in osteoblast
- VernacularTitle:成骨细胞跨膜转运锌特性及其机制的初步研究
- Author:
Xiaobo CEN
;
Ruishu WANG
;
Li WANG
;
Hang WANG
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):83-86
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the kinetic character of zinc transport and its influencing factors in osteoblasts, and scientific evidence is expected to provide to clarify the role of zinc on bone development. METHODS 65Zn tracing method was used to evaluate kinetic character of zinc transport. RESULTS Increase of extracellular zinc level could enhance the influx of zinc, but when the osteoblast became zinc deficiency the influx of zinc decreased. The histidine, Na+、K+-ATPase enzyme inhibitor had no effect on zinc transport into the cell, but Ca2+ channel blocker could enhance the influx of zinc. CONCLUSION The excellular level of zinc could influence zinc transport into osteoblasts, and Ca2+ channel could interact with Zn2+ transport.
