The effect of bifico on rat experimental hepatic encephalopathy induced by thioaetamide
- VernacularTitle:培菲康对硫代乙酰胺诱导的大鼠肝性脑病的保护作用
- Author:
Jianfeng TIAN
;
Xiaoyu LI
;
Jianhua LIU
;
Yi SUN
;
Jianyi XU
;
Xiaomin LU
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):86-88
- CountryChina
- Language:Chinese
-
Abstract:
AIM The effect of bifico on experimental hepatic encephalopathy (HE) induced by thioacetamide(TAA) and the possible mechanism of its protective effect were studied. METHODS Experimental hepatic encephalopathy was induced by ig thioacetamide 250 mg*kg-1 successively for two days; bifico was administraed ig once per day for one week before HE induction. RESULTS Compared with control HE rat, Bifico improved rat neuro-reflexes score and hepatic injury grade(P<0.05); thus decreased rat serum ammonium and LPS concentrations, respectively (P<0.05,P<0.01). The preparation slightly increased the ratio of chain amino acid to aromatic amino acid as well as reduced the degree of liver necrosis. CONCLUSION At the dosage of 840 mg*kg-1 ig for one week before liver intoxication, Bifico significantly protects rats from hepatic encephalopathy induced by TAA.
