Effect of hydroxyl camptothecinum on pharmacokinetics of cyclosprine A and the membrane lipid fluidity of red cell in rabbit
- VernacularTitle:羟基喜树碱对家兔环孢A代谢和红细胞膜脂流动性的影响
- Author:
Guizhi WU
;
Duanhao FENG
;
Wei LIU
;
Ling SUN
;
Xianjie ZHANG
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):94-96
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of hydroxyl camptothecinum(HCPT) on pharmocokinetics of cyclosprine A(CsA) and the membrane lipid fluidity (LFU)of red cell in rabbits. METHODS The whole blood concentration of CsA in rabbits was monitored using method of FPIA. The LFU of red cell was measured using method of DPH fluorescence polarization technique. RESULTS The pharmocokinetic parameters of CsA in group CsA+HCPT such as a,V(c),K12 and CL(s) were significantly lower and T1/2(a) was significantly higher (P<0.05) than in group CsA. The concentration of CsA of group CsA+HCPT was higher after injection 0.25, 0.5 and 1.0 h, but have significantly high at 1.0 h point (P<0.05). After injection 0.5,1.0, 1.5 h the LFU of red cell in group CsA+HCPT was higher than in group CsA (P<0.05). The LFU in group CsA was lower that in control at 0.5,1.0 and 1.5 h point (P<0.05). CONCLUSION HCPT can enhance the whole blood concentration of CsA in rabbits. CsA administrated with HCPT is feasible.
