Effect of glycol mannate sulfate on experimental thrombosis
- VernacularTitle:单甘酯对实验性血栓形成的影响
- Author:
Bo JIAO
;
Yanna CHENG
;
Yuanyuan ZHU
;
Jianbo JI
;
Shiling ZHANG
;
Wei YUAN
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):96-98
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the antithrobosis effects of glycol mannate sulfate(GMS). METHODS Vein thrombus was formed in rat by ligating postcava. Thrombus formation in vitro was observed by Chandlers method. Clotting indexes were measure by ACL200 congulation system. RESULTS GMS dosage of 20、40 mg*kg-1 could inhibit the vein thrombus formation in rats (P<0.01). GMS could inhibit the thrombosis in rabbit, in vivo, and the inhibitory action was enhanced along with the increase of dosage. The CT,TT,CT,APTT,RT and PT were prolonged, and the fibrinogen and the activity of Ⅱ and Ⅱa were decreased. The activity of ATⅢ was enhenced. CONCLUSION GMS has antithrombotic effect and the mechanism may be related to the anticongulat effect.
