A new animal model of gastric cancer induced by MNNG‘sattacking combining ulcer
- VernacularTitle:硝酸结合MNNG攻击大鼠胃癌模型与评价
- Author:
Bengjie ZHOU
;
Weiweng CHENG
;
Jinghua WUAN
;
Zhongsheng KUANG
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(1):111-112
- CountryChina
- Language:Chinese
-
Abstract:
AIM To establish a new animal model of gastric cancer with high incidence rate and short experimental period. METHODS Using N-methyl-N′-nitro-N-nitrasoguanidine(MNNG) combining ucler to induce rats to gastric cancer, taking the pathological situation of rats as the standard of canceration. RESULTS Six rats coming from model group were found as gastric cacinoma, the incidence rate of gastric cancer can reach forty percent. CONCLUSION This method can induce high incidence rate of gastric cancer during short experimental period. It deserves imroving and developing.
