A Comparison between the Effects of Losartan and Fosinopril,Captopril on the Excretion Rate of Urinary Albumin and the Clearance of Endogenous Creatinine in Elderly Hypertensive Patients
- VernacularTitle:氯沙坦与福辛普利、卡托普利对老年高血压患者尿白蛋白排泄量和内生肌酐清除率的对比研究
- Author:
Hongzan JI
;
Junzhong YANG
;
Xiaoyun QIAO
- Publication Type:Journal Article
- From:
Chinese Circulation Journal
2001;16(1):36-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of losartan、fosinopril and captopril on the excretion rate of urinary albumin (UAER) and the clearance of endogenous creatinine (Cr-C) in elderly patients. Methods:In this study,162 elderly patients with stage of the 2—3 class hypertension were included,The patients were divided into 3 groups,that were losartan group and the fosinopril group and captopril group,the anti-hypertensive effects and UAER and Cr-C were determined before and after the treatment. Results:The hypertensive effect rates were 94% in losartan group and 93%、93% in fosinopril group and captopril group respectively.Decrease of UAER was observed in 89% of patient in losartan group and 59%、50% in fosinopril group、captopril group.Cr-C were improved in 94%、78% of patient in losartan group and in fosinopril group and 63% in captopril group. Conclusions:Losartan has better effects on UAER and Cr-C than captopril in elderly hypertensive patients.
