Study on Relationship Between Chinese Budd-Chiari Syndrome and Factor Ⅴ Leiden Mutation
- VernacularTitle:国人布-加综合征与FⅤ Leiden突变的相关研究
- Author:
Bo FENG
;
Ke XU
;
Hong JIANG
;
Chunyuan JIN
;
Weineng FU
;
Fucai LI
;
Hong LI
;
Hongying SU
;
Xitong ZHANG
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(1):53-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Our aim was to study the relationship between factor v Leiden (FⅤL) mutation and Chinese Budd-Chiari syndrome (BCS). Methods:Twenty-nine BCS patients (25 patients with sporadic BCS,4 with familial BCS ),29 healthy persons were detected for FⅤL mutation with PCR-RFLP.Results: FⅤL mutation was detected in 3 of 4 patients with familial BCS. Two patients in A family and one patient in B family had FⅤL mutation. The mutation was heterozygous. The mutation frequency was 0.0517 in 29 pationts with BCS, 0.3750 in 4 with familial BCS.The frequency of FⅤL mutation in patients and healthy persons showed no statistical difference,but frequency of FⅤL mutation between patients with familial BCS and healthy persons showed significant difference.Conclusion:The FⅤL mutation was related to Chinese familial BCS, but not related to Chinese BCS.
