Effects of chitosan on hepato-mitochondria in fatty liver rats by stereologic analysis
- VernacularTitle:壳聚糖对实验性脂肪肝大鼠肝及线粒体的体视学分析
- Author:
Xiaohong QI
;
Li JIANG
;
Xiaoyu LI
;
Yuehua LI
;
Cuizhen WU
- Publication Type:Journal Article
- From:
Chinese Journal of Biochemical Pharmaceutics
2001;22(1):8-9
- CountryChina
- Language:Chinese
-
Abstract:
Purpose The aim is to study the preventing effect and me chanism of chitosan on fatty liver rats.Methods The rats give n a lo w dose of carbon tetrachloride(CCl4) and fed a high-fat diet to induce fatty liver model were treated with chitosan in different concentrations.The extensio n of steatosis area and changes in mitochondrial ultrastructure in liver were es timated by a computer color image analysis system and a quantitative analysis(st ereology).Results When rats were treated with a mid dose of c hitosan [4g/(kg*d)],the degree of hepatocytic steatosis was markedly diminished, and the injured mitochondrial structure was improved compared with model group.Co nclusion It was suggested that chitosan might enhance the oxidative catabolism of lipid in fatty liver.
