Prognostic factors in cholangiocarcinoma
- VernacularTitle:影响胆管癌预后的因素
- Author:
Yantai ZOU
;
Zhaolong LI
- Publication Type:Journal Article
- Keywords:
BILE DUCT NEOPLASMS/diag;
PROGNOSIS;
REVIEW LITERATURE
- From:
Chinese Journal of General Surgery
2001;10(1):71-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prognostic factors in cholangocarcinoma(CC). Methods Retrospective analysis of the reported clinical data of CC in lectures. Results and Conclusions The prognosis of CC in lower portion of bile duct(BD) is much better, CC in meddle portion of BD take the second place of prognosis, CC in upper portion of BD has the worst prognosis. If CC with following cases, which would have much better prognosis: higher differentiation without metastasis, diploid, higher PCNA; if CC with negative expression of epithelial membrane antigen or keratine, which would have worse prognosis. The activate of type IV collegen is related linearly to the metastasis capacity of the tumor, and the expression of nm23 of tumor is related to invation, lymphatic metastasis and prognosis of the tumor. Radical resection of the tumor has the best effect, palliative resection take the second place of prognosis, internal or external drainage operation has the worst effect. The effect of local radiotherapy is limited, and chemotherapy showes no effect. Early diagnosis, radical or extending resection and combined therapy can improve the prognosis of CC.
