THE STUDY OF PHARMACOKINETICS OF 5-Fu AFTER LEFT GASTRIC ARTERY INTRA-ARTERIAL INFUSION IN TREATMENT OF GASTRIC CARCINOMA

VernacularTitle:胃左动脉区域灌注化疗治疗胃癌的药代动力学研究
Author: Zhidong ZHU ; Yongdong PU
Publication Type:Journal Article
From: Chinese Journal of Bases and Clinics in General Surgery 2001;8(1):26-28
CountryChina
Language:Chinese
Abstract: Objective To evaluate the legitimate of regional artery infusion chemotherapy in the treatment of gastric carcinoma. Methods　The pharmacokinetics of 5-Fu after different route of administration was studied. Results High concentration of 5-Fu found in portal vein via left-gastric intra-artetial administration were 4-40 folds higher than the group via intravenous administration.The time of high concentrations of 5-Fu via left-gastric intra-arterial administration maintained significantly longer than by intravenous administraion. The concentration of 5-Fu in tumor tissues and paratumorous lymph tissues by intra-arterial administration were 19 times and 23 times of the group by intravenous administration. Conclusion Regional arterial infusion chemotherapy can significantly increase the concentration of chemotherapeutic drugs in the tumorous region.