STUDY ON ADRIAMYCIN-POROUS TRICALCIUM PHOSPHATE CERAMIC DRUG DELIVERY SYSTEM AND ITS DRUG RELEASE TEST IN VIVO
- VernacularTitle:阿霉素-多孔磷酸三钙陶瓷缓释体的研制及体内释药试验
- Author:
Hongbo YOU
;
Anmin CHEN
;
Shuzhen SUN
- Publication Type:Journal Article
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2001;15(1):12-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To manufacture adriamycin-porous tricalcium phosphate (A-PTCP) ceramic drug delivery system (DDS)as a possible method for bone defect treatment after bone tumor operation. Methods A-PTCP DDS was made from putting adriamycin into PTCP. Thirty rabbits were divided randomly into group A(24 rabbits) and group B(6 rabbits). A-PTCP was implanted in the greater trochanter of the right femur in group A. Adriamycin were injected into veins in group B. Muscle around A-PTCP and plasma were taken out at different period. Adriamycin concentrations in muscle and plasma were measured by high performance liquid chromatography (HPLC). Results A-PTCP could gradually release adriamycin over 10 weeks. Adriamycin concentrations in the muscle were higher than that in plasma. Conclusion A-PTCP may be a new method for repairing bone defects after bone tumor operation.
