Study on bioavailability of domestic acyclovir chewable tablets
- VernacularTitle:国产阿昔洛韦咀嚼片人体生物等效性研究
- Author:
Shaohua WANG
;
Baodong YU
;
Xiao CHU
;
Jie SHI
;
Jincai YU
;
Meiling ZHAO
- Publication Type:Journal Article
- Keywords:
acyclovir;
bioavailability;
HPLC;
bioequivalence
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2001;6(1):51-53
- CountryChina
- Language:Chinese
-
Abstract:
Aim To compare the relative bioavailabilities of domestic acyclovir chewabletablets and normal tablets. Methods A single oral dose of 800 mg acyclovir chewable tablets or normal tablets was given to 8 volunteers respectively in a randomized, cross-over study, acyclovir serum concentration was determined by high performance liquid chromatography. Results The AUC of chewable and normal tablets was respectively 0.42 and 0.40 μg · ml · h-1, and the relative bioavailability of a cyclovir chewable tablets was (105.8 + 13.1) %. Conclusion The chewable tablets and reference tablets is bioequivalent in AUC.
