A study onmemory function of cerebral multi-infarct dementia rat model
- VernacularTitle:多发性脑梗塞痴呆大鼠的记忆与再记忆功能测定的实验研究
- Author:
Minxia GUO
;
Shixum YU
;
Rui LI
- Publication Type:Journal Article
- From:
Chinese Journal of Rehabilitation Medicine
2001;16(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To elucidate the effect of cervical multi-infarction on memory function. Method: Homogenous microthrombi were injected into internal carotid artery(ICA) through external carotid artery of Sprangue-Dawlay rat to get unilateral,bilateral or recurrent embolic cerebral multi-infarcction model. Water maze and passive-avoidance tests were used to assess the memorial function. Brain histopathological changes were also conducted. Result: Memorial function was severely injured,on the contrast to the pseudo-operational rats. Among the three models, unilateral,bilateral and recurrent ones, recurrent multi-infarction model is the worst on the memorial function, while the bilateral group is worse. Conclusion: Cerebral multi-infarction can cause memorial dysfunction. The degree of memorial function is closely related to the degree of ischemic severity.
