Effect of soluble chitosan on antitumor in rats
- VernacularTitle:水溶性壳聚糖抗肿瘤作用的实验研究
- Author:
Fangyu WANG
;
Shuya HE
;
Bangliang LI
;
Shurong FEI
- Publication Type:Journal Article
- From:
Chinese Journal of Biochemical Pharmaceutics
2001;22(1):21-22
- CountryChina
- Language:Chinese
-
Abstract:
Purpose The aim is to study the effects of solubl e chit osan on antitumor factors and NK cell activity in rats.Methods The level of NO、TNF produced by peritoneal macrophages,IFN-γ production and NK ce ll activity of spleen was detected,after different concentrations of chitosan we re injected into the sarcoma 180 rats peritoneally.Results Th e cont ents of NO、TNF、IFN-γ and NK cell activity in sacroma 180 rats were significa ntly higher in the chitosan groups than those in the control group (P＜0.01) .Conclusion Chitosan could impove the immune function in rats .
