Influence of tetramethylpyrazine on oxygen metabolism during the respi ratory burst of human neutrophiis
- VernacularTitle:四甲吡嗪对人类白细胞呼吸爆发氧代谢的影响
- Author:
Zhaohui ZHANG
;
Shaozu YU
;
Baolu ZHAO
- Publication Type:Journal Article
- Keywords:
pyrazines;
ligustrazine;
electron spin resonance;
chemiluminescence;
oxygen radicals;
antioxidants
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2001;6(1):8-11
- CountryChina
- Language:Chinese
-
Abstract:
AimTo investigate the influence of tetramethylpyrazine(ligustrazine, Lig) on oxygen consumption and superoxide during the respiratory burst of human neutrophils. MethodsIt was observed by using ESR spin trapping, spin probe oxymetry and luminol-dependent chemiluminesence(CL) . Results Lig had no influence on oxygen consumption during the respiratory burst of neutrophils(P＞0.05), but had remarkable inhibition on CL response generated by neutrophils(P＜0.01), and had scavenging effect on O2 and OH ·generated by neutrophils, which were demonstrated in xanthine/ xanthine oxidase system and Fentons reaction(P＜0.01) . ConclusionLig has no inhibiting effect on oxygen metabolic function of neutrophils,but protects tissue from injury caused by activated neutrophils through scavenging oxygen radicals.
