Effect of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats
- VernacularTitle:不同剂量valsartan应用对SHR血压和左室心肌肥厚的影响
- Author:
Hai TANG
;
Zuoying HU
;
Ting YANG
- Publication Type:Journal Article
- Keywords:
hypertension;
spontaneously hypertensive rat (SHR);
valsartan;
left ventricular hypertrophy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2001;6(1):12-14
- CountryChina
- Language:Chinese
-
Abstract:
AimTo evaluate the effects of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats (SHR) . MethodsEighteen SHR(fourteenweek-old, male) were divided into three groups (six rats in each group ): SHR control group in which the rats were fed with normal saline; low dose valsartan group in which the rats were fed with valsartan 8 mg· kg-1 · d-1 and high dose valsartan group in which the rats were fed with valsartan 24 mg · kg -1 · d-1, all for 8 weeks. The rats in the WKY control group(n ＝ 6) were fed with normal saline for 8 weeks. Results SBP, LVM/ BW and TDM of SHR were remarkably lower than those of the control after drug intervention, and the effect on SBP, LVM/ BW and TDM was most remarkable in the high dose valsartan group. ConclusionDifferent doses of valsartan can decrease SBP of SHR and inhibit the progression of ventricular hypertrophy.
