Effects of aspirin and verapamil alone or in combination on mesenteric microcirculation of rats
- VernacularTitle:阿司匹林、维拉帕米单用和合用对大鼠肠系膜微循环的影响
- Author:
Yimin SONG
;
Xuekun LI
;
Janmin TAN
;
Zengxi LI
;
Shan SHI
- Publication Type:Journal Article
- Keywords:
aspirin;
verapamil;
combination drug therapy;
microcirculation;
blood flow velocity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2001;6(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
AimTo study the effects of aspirin (Asp) and verapamil(Ver)alone or in combination on mesenteric microcirculation of rats. MethodsAcute microcirculation disturbance(AMD) was produced by highmolecular weight dextran(Mr 480, 000) 360 mg· kg-1 iv. Arteriol and venul blood flow velocity and diameter (ABFV, VBFV, AD, VD) and blood flow state(BFS) were observed by intravital microcirculation method. Results Asp 2.5, 5 mg · kg-i, Ver 0.3, 0.6 mg · kg-1,Asp+ Ver(1 + 0.15), (2. 5+ 0. 3) mg· kg-1 iv significant increase ABFV by 11.1%, 31.3%, 18.7%,19.5%, 26.5%, 37.3%, VBFV by 12.5%, 5.7%, 2.5%, 3.7%, 30%, 34.7%,AD by 4.3%, 17.9%, 31.5%, 35%, 20%, 38.1% and VDby 2.2%,4.2%, 25%, 31.5%,5.8%,23.5%espectively, and got a raise in the number of capillaries and a marked improvement of BFS. Asp + Ver(1+0.15, 2.5+0.3) mg · kg-1 iv could reverse AMD. Conclusion Asp is superior to Ver in the increase of BFV, but Ver is superior to Asp in expansion of blood vessel. Asp in combination with Ver produces marked synergistic action and protection againist AMD.
