Effects of glipizide and metformin on serum insulin-like growth factor-1, 2 in patients with type Ⅱ diabetes mellitus
- VernacularTitle:格列嗪及二甲双胍对Ⅱ型糖尿病人血清胰岛素样生长因子-1,2的影响
- Author:
Jianhao PEI
;
Huazhang YANG
;
Jian KUANG
;
Xiaozhen LIAO
;
Chong CHENG
;
Hongmei CHENG
;
Zhongwen LI
;
Yantang CUI
- Publication Type:Journal Article
- Keywords:
insulin-like growth factor;
type Ⅱ diabetes mellitus;
glipizide;
metformin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2001;6(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
AimTo study the effects of glipizide and met formin on the serum IGF-1,IGF-2 in patients with type Ⅱ diabetes mellitus; Methods The effect of glipizide(n ＝ 40) and metformin(n ＝ 25) on serum IGF-1, IGF-2 in patients with type Ⅱ diabetes mellitus were compared with self- controlled study. Results In metformin-treated patients ,there were not significantly changes in fasting IGF-1 and IGF-2 concentrations, In glipizide-treated patients, there were markedly increased IGF-1 concentrations(181.8+ 104.5) vs (209.0+ 88.2) ng· ml-1(P＜0.05) while serum IGF-2 was not change. There was a significant reduction of blood glucose in two groups at the end of treatment(both P＜0.01), but C-peptide level was markedly increased(P＜0.05) only in glipizide-treatedpatients.Conclusion The changes of IGF-1 is markedly different between metformin-treated and glipizide-treated patients with type Ⅱ diabetes mellitus.
