Experimental study of the Chinese herbs of Li Qi Huo Xue on preventing and treating the vascular endothelial cells injury in ratsl
- VernacularTitle:理气活血中药防治大鼠血管内皮细胞损伤的实验研究
- Author:
Jianhong ZHAO
;
Lin LIN
;
Hui CAO
;
Jifa GAO
;
Fanhe ZHU
- Publication Type:Journal Article
- Keywords:
li qi huo xue;
chinese herbs;
vascular endothelial cell;
rat
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2001;6(1):41-43
- CountryChina
- Language:Chinese
-
Abstract:
AimTo establish a model of the injury of the vascular endothelial cell(VEC) in rats and observe the function of Chinese herbs of Li Qi Huo Xue(LQHX) will prevent and treat the VEC injury. Methods30 SD rats weredivided into the control, the model and LQHX groups. The model of the VEC injury was established. It tried to demonstrate the effect of LQHX for the coagula tion and fibrinolysis function of the VEC by the C EC count,t-PA, PAI activity, 6-keto-PGF1αcontent and PAgTmax. Results In LQHX group as compared with those of the medol group, The CEC count was redued obviously(P＜0.01). t-PA activity was increased(P＜0.01), so did the percentage of active t-PA(P＜0.01), but PAI activity decreased (P＜0.05), 6-keto-PGF1α content increased (P＜0.01)α the PAgTmax decreasd (P ＜0.01) Conclution LQHX can enhance the anticoagulation and fibrinolysis activities. It is a more effective measure for the VEC protection.
