Experimental mouse model of Chlamydia pneumoniae strain pneumonitis
- VernacularTitle:肺炎衣原体肺炎的实验鼠模型
- Author:
Yi SHI
;
Jie YIN
;
Huawen ZHAN
;
Xin SU
;
Xirong XIA
;
Xiaojun ZHOU
;
Ping SHEN
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(1):6-8
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To evaluate mice as experimental animal for Chlamydia pneumoniae, a common cause of acute respiratory infections in human. Methods: Intranasal inoculation of Icr mice with C. Pneumoniae induced a prolonged course of lung infection, as demonstrated by persistence of lung pathology(60 days). Results: Icr mice were susceptible to C. pneumoniae. Lung pathology was characterized by patchy interstitial pneumonitis with predominately neutrophil leukocyte infiltration in the early(7 days) and lymphocytes infiltration in the later stages(14 days later) of infection. Conclusions:Icr mice were susceptible to C. pneumoniae and the mouse model is useful for the investigation of the pathogenesis of C. pneumoniae infection.
