Determination of cholesteryl ester transfer protein activity in patients with cardiocerebrovascular diseases
- VernacularTitle:心脑血管疾病患者胆固醇酯转运蛋白活性测定
- Author:
Zhengqing LOU
;
Yiyi ZHUANG
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate the relationship between the activity of cholesteryl ester transfer protein(CETP) and cardiocerebrovascular diseases. Methods:The CETP activity of 45 cases of coronary heart disease(CHD) and 26 cases of stroke were measured using the synthetic substrate of 14 C-radiolabeled discoidal bilayer particles as the cholesteryl ester donor and LDL as receptor. Results:The CEPT activity(x±s) of CHD and stroke patients were(17.6±5.4)% and(15.2±3.8)%,while the healthy controls were(12.7±2.0)%.The CEPT activities in CHD and stroke patients were significantly higher than that in healthy controls(P<0.01). Conclusions: CETP is related to the occurrence and development of atherosclerosis.
