Cyclophilin A and infectivity of human immunodeficiency virus type-1
- VernacularTitle:亲环素A与HIV-1的感染性
- Author:
Fangqiu LI
;
Jianguo WU
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Cyclophilin A（CyPA） is a cytoplasmic protein which binds to immunosuppressive drug—cyclosporin A and possesses peptidyl-prolyl cis-trans isomerase activity. CyPA incorporated into virions through interactions with the Gag polyprotein in the life cycle of human immunodeficiency virus type 1(HIV-1) and its incorporation is essential for viral infectivity. This review discussed the function of CyPA in replication of HIV-1 virion and the usefulness of these studies for anti-HIV therapies.
