ISOLATION AND IDENTIFICATION OF STEROIDAL SAPONINS FROM DIOSCOREA PANTHAICA PRAIN ET BURKILL
- VernacularTitle:黄山药中甾体皂苷的分离与鉴定
- Author:
Mei DONG
;
Lijun WU
;
Quan CHEN
;
Benxiang WANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the chemical constituents of the rhizomes of Dioscorea panthaica Prain et Burkill and look for new active compounds. METHODS The compounds were isolated with silica gel and HPLC, and their structures were elucidated on the basis of chemical evidences and spectral analysis (IR, ESI-MS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HMQC, HMBC, NOESY). RESULTS Three steroidal saponins were isolated from the rhizomes of Dioscorea panthaica. They were elucidated as 26-O-β-D-glucopyranosyl-3β,26-diol-23(S)-methoxy-25(R)-Δ5,20(22)-diene-furosta-3-O-［α-L-rhamnopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)］-β-D-glucopyranoside (I), pseudoprotodioscin (II), 26-O-β-D-glucopyranosyl-3β,26-diol-25(R)-Δ5,20(22)-diene-furosta-3-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranoside (III). CONCLUSION Compound I is a new steroidal saponin and was named as dioscoreside C. Compound II and III were obtained from this genus for the first time.
