Changes of pulmonary malondialdehyde ,glutathione and total-antioxidation content in SD rat with nitrogen dioxide exposure
- VernacularTitle:SD大鼠二氧化氮吸入性肺损伤实验研究
- Author:
Yongying XIAO
;
Xirong XIA
;
Yi SHI
;
Maorong TONG
;
Xilong ZHANG
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(1):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate lung injury mechanism in SD rat with nitrogen dioxide(NO2) exposure. Methods:In the test-control study, pulmonary malondialdehyde(MDA),glutathione(GSH) and total-antioxidant content(T-AOC) were determined in 10 SD rats with long-term NO2 exposure,10 SD rats with short-term NO2 exposure and 10 SD rats with fresh air as control. Results: Pulmonary MDA content was increased and T-AOC was decreased significantly in SD rat exposed to NO2. Pulmonary GSH was decreased significantly in long-term NO2 exposure group as compared with short-term NO2 exposure group and control group. Conclusions: Imbalance between oxidant and antioxidant was an important mechanism in the pathogenesis of oxidizing lung injury in SD rat with NO2 exposure.
