Analysis of Inheritance in Infantile Nystagmus.
- Author:
Ik Soo KIM
1
;
Sang Chul PARK
Author Information
1. Department of Ophthalmology, Kangnam St. Mary's Hospital, Catholic University, Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Autosomal dominant;
Infantile nystagmus;
Inheritance pattern;
Irregular dominant;
X-linked recessive
- MeSH:
Humans;
Inheritance Patterns;
Parturition;
Penetrance;
Wills*
- From:Journal of the Korean Ophthalmological Society
1996;37(6):1054-1061
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Infantile nystagmus is characterized by involuntary oscillations of one or both eyes being present at birth or shortly thereafter without systemic or ophthalmologic lesions. Its inheritance pattern is not known exactly, but three types have been distinguished; irregular dominant, sex linked recessive, and simple recessive patterns. We observed 15 patients with family history and analyzed the characteristics of their inheritance patterns. We concluded the patterns of inheritance are irregular X-linked or autosomal dominant inheritance with incomplete penetrance in 7 families(47%), X-linked recessive or autosomal dominant inheritance in 5 families(33%), and autosomal dominant inheritance in 3 families(20%), respectively.
