Study on Cytotoxic Effect and Antitumor Effect of Paclitaxel Liposome
- VernacularTitle:紫杉醇脂质体细胞毒作用和抗瘤作用的研究
- Author:
Fengying WEI
;
Wencai CHENG
- Publication Type:Journal Article
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2001;30(1):46-49
- CountryChina
- Language:Chinese
-
Abstract:
The cytotoxic effect and antitumor effect of paclitaxel liposome were studied by using MTT assay method in vitro and in vivo antitumor test. The inhibitory rate of paclitaxel liposome on human ovarian cancer cell COC1 was 78.48 %, 84.90 %, 93.53 % respectively at the concentrations of 22.5 μg/ml, 45 μg/ml, 90 μg/ml respectively. Under the doses of 5 mg/(kg*d) and 10 mg/(kg*d) for 8 days, the inhibitory rate of paclitaxel liposome against xenograft of solid Ehrlich tumor in mice was 32.47 % and 54.63 % respectively (P<0.01). The weight change rate of the mice was 22.11 % and 21.16 % respectively. It was suggested that paclitaxel liposome possessed in vitro and in vivo antitumor activities. The toxicity of liposomal paclitaxel was lower than that of free paclitaxel.
