Effect of pravastatin preconditioning on myocardial ischemia-reperfusion injury in patients undergoing Valve replacement with CPB
10.3760/cma.j.issn.0254-1416.2011.02.006
- VernacularTitle:普伐他丁预处理对体外循环下心脏瓣膜置换术患者心肌缺血再灌注损伤的影响
- Author:
Qi CHEN
;
Ye ZHANG
;
Yongsheng SONG
- Publication Type:Journal Article
- Keywords:
Pravastatin;
Ischemia preconditioning;
Myocardial reperfusion injury;
Cardiopulmonary bypass
- From:
Chinese Journal of Anesthesiology
2011;31(2):157-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of preoperative pravastatin preconditioning on myocardial ischemia-repedusion(I／R)injury in patients undergoing cardiac valve replacement with cardiopulmonary bypass (CPB).Methods Sixty ASA Ⅱ orⅢpatients of both sexes aged 18-64 yr undergoing cardiac valve replacement under CPB were randomly divided into 4 groups(n=15 each)：control group(group C)and 3 pravastatin groups receiving oral pravastatin 10，20 and 40 mg respectively every night for 7 days before operation(group P1-3).The number of patients receiving dopamine(≥5 μg·kg-1·min-1)and adrenaline was recorded from the termination of CPB to the end of operation，from the end of operation to 12 h after operation，during 12-24 h after operation and during 24-48 h after operation.Venous blood samples were taken from central venous line for measurement of plasme cTnI and CK-MB concentrations at 7 days before operation，before induction of anesthesia，at opening of the aorta and at 2，24 and 48 h after opening of aorta.Results The number of patients receiving dopamine and adrenaline was significantly less in group P3 than in group C(P<0.05).Plasma CK-MB and cTnI concentrations were significantly lower in group P3 than in group C(P<0.05).Conclusion Preconditioning with oral pravastatin(40mg／d for 7 consecutive days)can protect myocardium against I／R injury in patients undergoing cardiac valve replacement with CPB.
