Experimental pathology study on the effect of ACR on axon of both Ola mice and 6J mice

VernacularTitle:丙烯酰胺对变异Ola鼠和正常6J鼠轴突影响的实验研究
Author: Qiuyue HE ; Manfu HAN ; Mingli RAO
Publication Type:Journal Article
Keywords: ACR; mouse; degeneration
From: Journal of Jilin University(Medicine Edition) 2000;26(6):573-576
CountryChina
Language:Chinese
Abstract: Objective :To observate the axon changes in pathology of Ola mice,compared with those of 6Jmice. Methods:The peroneal nerve and sural nerve were studied by light-microscope and electronmi-croscope. Results :In light-microscope,the total transverse fascicular area was significantly large ;density ofmyelinated fibers was significantly less;the maximal diameter of myelinated fibers was significantly less;minimal diameter of myelinated fibers had no changens in 6J mice. The Ola mice were nomal. In electronmi-croscope observation, the neurofilament was accumulated within axons. Conclusion: In Ola mice treatedwith ACR,the like-Wallerian degeneration wes delayed. However,in 6J mice the neurofilament and mito-chondria accumulation was found within axons.