Analysis 0f existing condition 0f human papillomaVirus DNA in tongue Cancer
- VernacularTitle:人乳头瘤病毒在舌癌细胞中存在状态分析
- Author:
Zebing ZHANG
;
Wentao GAO
;
Jie OUYANG
;
Ming ZHENG
- Publication Type:Journal Article
- Keywords:
tongue;
cancer;
HPV;
gene integration
- From:
Journal of Jilin University(Medicine Edition)
2000;26(6):577-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To find out the existing pattern of HPV16 in tongue cancer cell and to analyze itsrole in carcinogenesis of tongue cancer. Methods :Southern blot hybridization was used to detect the HPV16sequence and its existing condition in 20 cases of fresh human tongue cancers. Results:HPV16 DNA se-quence in 5 cases of 20 tongue cancers was detected. And HPV16 DNA existed in tongue cancer cell in non-integration pattern. Conclusion:HPV16 was involved in carcinogenesis of tongue cancer through interactionof HPV gene products rather than its integration with genome of target cell.
