Role of IL-6 in the contraceptive mechanism of intrauterine device
- Author:
Dan ZHU
;
Liyan WANG
;
Li FU
;
Ruiying JIA
- Publication Type:Journal Article
- Keywords:
intrauterine contraceptive devices;
interleukin-6;
C-reactive protein
- From:
Journal of Jilin University(Medicine Edition)
2000;26(6):597-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the relationship between the serum level of interleukin-6 (IL-6) and the presence of an intrauterine contraceptive device (IUCD). Methods:The experimentalgroup was subdivided into the bleeding and the non-bleeding groups which consisted of 64 womenwith IUCD. There were 60 healthy women in the control group. The serum levels of IL-6 and C-reactive protein (CRP) were detected by enzyme-linked immunosorbent assay (ELISA) in bothgroups. Results :In the experimental group,the serum levels of IL-6 in 3 cases were increased,andthere was a significant difference in comparison with those of the control group (P＜0. 01),butthere were no statistical differences between the bleeding group and the non-bleeding group withIUCD (P＞0． 05). Serum CRP was negative both in the experimental groups and in the controlgroup. Conclusion:The non-bacterial endometrial inflammation induced by IUCD causes the in-crease of serum level of IL-6 in some women. It is suggested that IL-6 may play an important rolein the contraceptive mechanism of IUCD.
