Astragalus Polysaccharide Prevent Type 1 Diabetes in Nonobese Diabetic Mice
- VernacularTitle:黄芪多糖对NOD小鼠1型糖尿病的预防作用
- Author:
Wei CHEN
;
Fang LIU
;
Maohua YU
;
Qiuyu ZHU
;
Xixing ZHU
- Publication Type:Journal Article
- From:
Fudan University Journal of Medical Sciences
2001;28(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the effects of the intervention or prevention of astragalus polysaccharide(APS)on type 1 diabetes in non-obese diabetic(NOD) mice. Methods the APS group was compared withthe normal solution(NS)group by the incidence of diabetes, the serum C-peptide levels and GAD-Ab levels,the proportion of CD4 or CD8 T subsets in splencytes, pancreatic histopathology and immunocyto-chemistry.Results It shows that the APS group has lower incidence of diabetes, higher serum C-P levels, decreaseddegree of the lymphocytic inflammation of pancreatic islets, stronger proliferation of CD8 T subsets and lowerratio of CD4/CD8 subgroup in splencytes than those of the NS group. Conclusions It proves thepreventive effects of APS on the onset of type 1 diabetes in NOD mice.
