The genetic immunization in mice with three constructs of Toxoplasma gondii SAG1 gene
- VernacularTitle:三种表达形式的SAG1基因对小鼠的免疫效果观察
- Author:
Xiaoguang CHEN
;
Xiaohong ZHOU
;
Ya GONG
;
Peiliang YANG
;
Shuman SHEN
;
Mingchiu FONG
;
Zhaorong LUN
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
SAG1;
immunization
- From:
Journal of Tropical Medicine
2001;1(1):3-9
- CountryChina
- Language:Chinese
-
Abstract:
Three forms of the major surface antigen (SAG1)of Toxoplasma gondii, that is the membrane form, the secrete form and the intracellular form, were constructed and used to immunize BALB/c mice. The humoral response in the mice immunized with the membrane form and the secrete form of SAG1 appeared earlier and stronger than those mice immunized with the intracellular form. Result from the challenging infection demonstrated that the protection in the mice immunized with the membrane and the secrete forms was also stronger than in the mice immunized with the intracellular form. We suggest that the immune efficiency of the three forms of SAG1 in the mouse model is different.
